A DNA polymerase epsilon inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation
Language English Country Great Britain, England Media print
Document type Journal Article
PubMed
11557057
DOI
10.1016/s0014-5793(01)02808-3
PII: S0014579301028083
Knihovny.cz E-resources
- MeSH
- Diphosphonates pharmacology MeSH
- Deoxyribonucleotides metabolism MeSH
- DNA Primers metabolism MeSH
- DNA Polymerase I metabolism MeSH
- DNA Polymerase II antagonists & inhibitors MeSH
- DNA Primase drug effects metabolism MeSH
- Enzyme Inhibitors pharmacology MeSH
- Mimosine metabolism MeSH
- Ribonucleotides metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Diphosphonates MeSH
- carbonyldiphosphonate MeSH Browser
- Deoxyribonucleotides MeSH
- DNA Primers MeSH
- DNA Polymerase I MeSH
- DNA Polymerase II MeSH
- DNA Primase MeSH
- Enzyme Inhibitors MeSH
- Mimosine MeSH
- Ribonucleotides MeSH
Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) epsilon, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr-DNA pol alpha enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J. Ríman and A. Sulová, Acta Virol. 41 (1997) 181-214]. Besides stimulation, COMDP uncouples the Pr activities from those of DNA pol alpha, inducing in this way a unique phenomenon of accumulation of primers of basic length. In the presence of dNTPs, the COMDP effect is counteracted by excess of mimosine. The mutually exclusive effects of these agents are discussed.
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