Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11563123
DOI
10.1081/ncn-100002437
Knihovny.cz E-resources
- MeSH
- Adenosine Monophosphate chemistry MeSH
- Oligonucleotides, Antisense chemical synthesis chemistry metabolism MeSH
- Nucleic Acid Hybridization MeSH
- Organophosphonates chemistry MeSH
- Cross-Linking Reagents chemistry MeSH
- Ribonuclease H metabolism MeSH
- Thymidine Monophosphate chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine Monophosphate MeSH
- Oligonucleotides, Antisense MeSH
- Organophosphonates MeSH
- Cross-Linking Reagents MeSH
- Ribonuclease H MeSH
- Thymidine Monophosphate MeSH
Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
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