In vitro reaktivace acetylcholinesterázy inhibované O-isopropylmethylfluorofosfonátem uzitím biskvarterního oximu HS-6
[In vitro reactivation of acetylcholinesterase inhibition by O-isopropylmethylfluorophosphonate using the bisquarternary oxime, HS-6]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
15095579
- MeSH
- Acetylcholinesterase metabolism MeSH
- Enzyme Activation drug effects MeSH
- Enzyme Activators pharmacology MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- Rats MeSH
- Brain enzymology MeSH
- Pralidoxime Compounds pharmacology MeSH
- Sarin pharmacology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Enzyme Activators MeSH
- Cholinesterase Inhibitors MeSH
- HS 6 MeSH Browser
- Pralidoxime Compounds MeSH
- Sarin MeSH
The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerve agent sarin [O-isopropylmethylfluorophosphonate] was evaluated. The reactivators 2-PAM [2-hydroxyiminomethyl-1-methylpyridinium chloride], toxogonin [1,3-bis(4-hydroxyiminomethylpyridinium)-2-oxa-propane dichloride] and H-oxime HI-6 [1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] were chosen for comparison. The oxime HS-6 was an effective reactivator of sarin-inhibited AChE. It is not as effective as the H-oxime HI-6, but it is better than 2-PAM and obidoxime.
