Nucleosidyl-O-Methylphosphonates: a pool of monomers for modified oligonucleotides
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15598072
DOI
10.1081/ncn-200033912
Knihovny.cz E-resources
- MeSH
- Deoxyribonucleosides chemistry metabolism MeSH
- Oligodeoxyribonucleotides chemical synthesis MeSH
- Organophosphonates chemistry metabolism MeSH
- Organophosphorus Compounds chemistry metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Deoxyribonucleosides MeSH
- methylphosphonic acid MeSH Browser
- Oligodeoxyribonucleotides MeSH
- Organophosphonates MeSH
- Organophosphorus Compounds MeSH
An unique set of 5'-O- and 3'-O-phosphonomethyl derivatives of four natural 2'-deoxyribonucleosides, 1-(2-deoxy-beta-D-threo-pentofuranosyl)thymine, 5'-O- and 2'-O-phosphonomethyl derivatives of 1-(3-deoxy-beta-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-beta-D-threo-pentofuranosyl)thymine, has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step.
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