Biological half-life of bromide in the rat depends primarily on the magnitude of sodium intake
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15717853
PII: 691
Knihovny.cz E-resources
- MeSH
- Bromides administration & dosage pharmacokinetics urine MeSH
- Sodium Chloride administration & dosage MeSH
- Sodium Bicarbonate administration & dosage MeSH
- Rats MeSH
- Perchlorates administration & dosage MeSH
- Half-Life MeSH
- Rats, Wistar MeSH
- Bromine Radioisotopes MeSH
- Sodium Radioisotopes MeSH
- Potassium Compounds administration & dosage MeSH
- Sodium Compounds administration & dosage MeSH
- Sodium administration & dosage pharmacokinetics urine MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bromides MeSH
- Sodium Chloride MeSH
- Sodium Bicarbonate MeSH
- Perchlorates MeSH
- potassium bromide MeSH Browser
- Bromine Radioisotopes MeSH
- Sodium Radioisotopes MeSH
- Potassium Compounds MeSH
- Sodium Compounds MeSH
- Sodium MeSH
- sodium perchlorate MeSH Browser
The parallel course of the excretion rates of bromide and sodium ions was demonstrated in adult male and female rats administered simultaneously with potassium 82Br-bromide and 24Na-sodium chloride. The animals were exposed to various intakes of sodium ions accompanied with five different anions: Br-, Cl-, HCO3-, ClO4-, and SCN-. Regardless of the anion accompanying the sodium ion, the excretion rates of 82Br- and 24Na+ ions were proportional to the magnitude of sodium intake in the animals. Hence, we have proved our hypothesis that the biological half-life of bromide depends on the magnitude of sodium intake rather than on the intake of chloride.
