Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15723861
DOI
10.1177/154405910508400304
PII: 84/3/228
Knihovny.cz E-resources
- MeSH
- Apoptosis physiology MeSH
- Ectodermal Dysplasia embryology genetics MeSH
- Ectodysplasins MeSH
- Epithelium embryology MeSH
- Gestational Age MeSH
- Mice, Inbred Strains MeSH
- Mandible embryology MeSH
- Membrane Proteins genetics MeSH
- Morphogenesis physiology MeSH
- Mice, Mutant Strains MeSH
- Mice MeSH
- Odontogenesis physiology MeSH
- Enamel Organ embryology MeSH
- Image Processing, Computer-Assisted methods MeSH
- Cheek embryology MeSH
- Imaging, Three-Dimensional methods MeSH
- Tooth Germ embryology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Eda protein, mouse MeSH Browser
- Ectodysplasins MeSH
- Membrane Proteins MeSH
In wild-type (WT) mice, epithelial apoptosis is involved in reducing the embryonic tooth number and the mesial delimitation of the first molar. We investigated whether apoptosis could also be involved in the reduction of tooth number and the determination of anomalous tooth boundaries in tabby (Ta)/EDA mice. Using serial histological sections and computer-aided 3D reconstructions, we investigated epithelial apoptosis in the lower cheek dentition at embryonic days 14.5-17.5. In comparison with WT mice, apoptosis was increased mainly mesially in Ta dental epithelium from day 15.5. This apoptosis showed a similar mesio-distal extent in all 5 morphotypes (Ia,b,c and IIa,b) of Ta dentition and eliminated the first cheek tooth in morphotypes IIa,b. Apoptosis did not appear to play any causal role in positioning inter-dental gaps. Analysis of the present data suggests that the increased apoptosis in Ta mice is a consequence of impaired tooth development caused by a defect in segmentation of dental epithelium.
References provided by Crossref.org
Role of Cell Death in Cellular Processes During Odontogenesis