Markers of inflammation in preeclampsia
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15782556
Knihovny.cz E-resources
- MeSH
- Antibodies, Anticardiolipin blood MeSH
- Biomarkers blood MeSH
- C-Reactive Protein analysis MeSH
- Adult MeSH
- Immunoglobulin G blood MeSH
- Immunoglobulin M blood MeSH
- Blood Proteins metabolism MeSH
- Humans MeSH
- Inflammation Mediators blood MeSH
- Oxidative Stress MeSH
- Pre-Eclampsia blood MeSH
- Pregnancy MeSH
- Free Radicals metabolism MeSH
- Inflammation MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antibodies, Anticardiolipin MeSH
- Biomarkers MeSH
- C-Reactive Protein MeSH
- Immunoglobulin G MeSH
- Immunoglobulin M MeSH
- Blood Proteins MeSH
- Inflammation Mediators MeSH
- Free Radicals MeSH
Advanced oxidation protein products (AOPP) represent terminal products of proteins exposure to free radicals. The aim of this study was to estimate the serum AOPP levels in preeclamptic patients together with ultrasensitive C-reactive protein and anticardiolipin antibodies (ACA) IgG and IgM. 21 women in the third trimester of pregnancy were included in the study--10 women with preeclampsia and 11 women with normal outcome of pregnancy. AOPP levels in preeclampsia were higher than those in normal pregnant women in the third trimester, but not statistically significantly. The comparison with AOPP levels in non-pregnant women has shown a significant increase (P<0.0001). CRP in preeclampsia was significantly increased in comparison with third trimester levels in normal pregnancy (P<0.001) as well as with non-pregnant women (P<0.0001). In preeclampsia, the ACA IgG levels were even significantly lower than in normal pregnant women in the same gestation age, but significantly higher than in non-pregnant women (P<0.001). No difference was found in ACA IgM in preeclampsia and normal third trimester pregnancy and non-pregnant women. A statistically significant negative correlation was found between AOPP and ACA IgG (r= - 0.708, P<0.05). The results indicate enhanced oxidative and inflammatory reaction of maternal organism to pregnancy, which is more pronounced in preeclampsia than in uncomplicated pregnancy.
