Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15848757
DOI
10.1016/j.bmc.2005.03.006
PII: S0968-0896(05)00199-9
Knihovny.cz E-resources
- MeSH
- Acylation MeSH
- Esters chemistry MeSH
- Betulinic Acid MeSH
- Phthalic Acids * chemical synthesis chemistry pharmacology MeSH
- Humans MeSH
- Tumor Cells, Cultured MeSH
- Neoplasms drug therapy MeSH
- Pentacyclic Triterpenes MeSH
- Antineoplastic Agents chemical synthesis chemistry pharmacology MeSH
- Drug Screening Assays, Antitumor MeSH
- Triterpenes * chemical synthesis chemistry pharmacology MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- betulin MeSH Browser
- Esters MeSH
- Betulinic Acid MeSH
- Phthalic Acids * MeSH
- Pentacyclic Triterpenes MeSH
- Antineoplastic Agents MeSH
- Triterpenes * MeSH
Synthesis of 3beta-O-phthalic esters from betulinic acid and its esters and synthesis of phthalic esters from betulin and its monoacetates using classical acylation procedure with phthalic anhydride. The evaluation of cytotoxicity of the prepared compounds was using numbers of tumor cell lines in MTT test. It was discovered that hemiphthalic esters had better cytotoxicity than starting compounds as betulinic acid or quite inactive betulin.
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