Incidence of Crohn disease in the Czech Republic in the years 1990 to 2001 and assessment of pediatric population with inflammatory bowel disease
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16456413
DOI
10.1097/01.mpg.0000189328.47150.bc
PII: 00005176-200602000-00014
Knihovny.cz E-resources
- MeSH
- Azathioprine therapeutic use MeSH
- Crohn Disease complications drug therapy epidemiology MeSH
- Child MeSH
- Adrenal Cortex Hormones therapeutic use MeSH
- Inflammatory Bowel Diseases complications drug therapy epidemiology MeSH
- Incidence MeSH
- Infant MeSH
- Colitis drug therapy epidemiology MeSH
- Drug Therapy, Combination MeSH
- Aminosalicylic Acids therapeutic use MeSH
- Humans MeSH
- Adolescent MeSH
- Growth Disorders etiology MeSH
- Child, Preschool MeSH
- Disease Progression MeSH
- Prospective Studies MeSH
- Retrospective Studies MeSH
- Colitis, Ulcerative complications drug therapy epidemiology MeSH
- Age Factors MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Azathioprine MeSH
- Adrenal Cortex Hormones MeSH
- Aminosalicylic Acids MeSH
BACKGROUND: The aim of this study was to assess the pediatric population that suffered from inflammatory bowel disease (IBD) in the Czech Republic and to determine the incidence of Crohn disease (CD) in children up to 15 years age between 1990 and 2001. METHODS: Diagnostic criteria for CD, ulcerative colitis (UC), and indeterminate colitis (IC) were defined. Medical records provided a source of basic information about the children. A standardized protocol was filled out and sent to the coordinator of the study. All protocols were checked to see whether the data corresponded to the defined criteria and then were processed further. The study was retrospective in character for the years 1990 to 1999 and prospective for the years 2000 and 2001. RESULTS: Diagnostic criteria were met in 470 patients with IBD; 201 of them turned 18 years old during the study period. CD was diagnosed in 223 patients. The incidence of CD in children up to 15 years of age increased from 0.25/100,000 in 1990 to 1.25/100,000 in 2001. Eighty-two percent of children with CD were treated with aminosalicylates in combination with corticosteroids; 29% of patients received azathioprine. Severe growth retardation was recorded in 6.4% of adolescents with CD at the age of 18. UC was diagnosed in 202 patients. Therapy with aminosalicylates only was sufficient for control of the disease in 23% patients; 68% children were treated with corticosteroids, 15 of them (23% of the whole group) received additional azathioprine. Criteria for IC were met in 9.8% of all patients with IBD. CONCLUSION: This study confirmed an increase in incidence of CD in children younger than 15 years in the Czech Republic.
References provided by Crossref.org
Current global trends in the incidence of pediatric-onset inflammatory bowel disease
Inflammatory bowel disease incidence in Czech children: A regional prospective study, 2000-2015
