Effects of N,N-bis(3-aminopropyl)dodecylamine on antioxidant enzyme activities, mitochondrial morphology and metabolism in Aspergillus niger
Language English Country United States Media print
Document type Journal Article
PubMed
16821710
DOI
10.1007/bf02931448
Knihovny.cz E-resources
- MeSH
- Amines pharmacology MeSH
- Antifungal Agents pharmacology MeSH
- Aspergillus niger drug effects metabolism ultrastructure MeSH
- Time Factors MeSH
- Fumarate Hydratase metabolism MeSH
- Glutathione Peroxidase metabolism MeSH
- Hyphae drug effects ultrastructure MeSH
- Enzyme Inhibitors pharmacology MeSH
- Catalase metabolism MeSH
- Mitochondria drug effects metabolism ultrastructure MeSH
- NADH Dehydrogenase metabolism MeSH
- Succinate Dehydrogenase metabolism MeSH
- Superoxide Dismutase metabolism MeSH
- Microscopy, Electron, Transmission MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Amines MeSH
- Antifungal Agents MeSH
- Fumarate Hydratase MeSH
- Glutathione Peroxidase MeSH
- Enzyme Inhibitors MeSH
- Catalase MeSH
- N,N-bis(3-aminopropyl)dodecylamine MeSH Browser
- NADH Dehydrogenase MeSH
- Succinate Dehydrogenase MeSH
- Superoxide Dismutase MeSH
The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSP) as well as of succinate dehydrogenase (SDG), NADH dehydrogenase (NDG) and fumarate hydratase (FHT) were examined in relation to mitochondrial ultrastructure changes in Aspergillus niger exposed to N,N-bis(3-aminopropyl)dodecylamine (Apd) that was shown to exhibit fungicidal activity. There was a progressive increase in SOD, CAT and GSP activities 1 and 4 h after 0.05 and 0.1 % Apd application. However, this was followed by a pronounced activity decrease when 0.05 % Apd treatment was prolonged by 1 d. The destructive effect on fungal morphology was observed when this fungicidal agent was applied at the concentration of 0.1 % for 1 d. In the treated hyphae mitochondria degenerated after all organelles. The morphological malformations of mitochondria had an impact on their metabolic state; however, the activities of SDG, NDG and FHT were affected to a different extent. In A. niger the fungicidal effect of Apd could be mediated by oxidative stress impairing the vital mitochondria-related cellular functions.
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