Changes of hippocampal neurons after perinatal exposure to ethanol
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17298200
DOI
10.33549/physiolres.931059
PII: 1059
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Ethanol toxicity MeSH
- Dentate Gyrus drug effects embryology growth & development pathology MeSH
- Hippocampus drug effects embryology growth & development pathology MeSH
- Rats MeSH
- Central Nervous System Depressants toxicity MeSH
- Longitudinal Studies MeSH
- Statistics, Nonparametric MeSH
- Neurons drug effects pathology MeSH
- Alcohol Drinking pathology MeSH
- Rats, Wistar MeSH
- Pregnancy MeSH
- Organ Size MeSH
- Prenatal Exposure Delayed Effects pathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ethanol MeSH
- Central Nervous System Depressants MeSH
The effect of ethanol on the structural development of the central nervous system was studied in offspring of Wistar rats, drinking 20 % ethanol during pregnancy and till the 28th day of their postnatal life. The structural changes in the hippocampus and dentate gyrus were analyzed at the age of 18, 35 and 90 days. A lower width of pyramidal and granular cell layers, cell extinction and fragmentation of numerous nuclei were found in all experimental animals compared to control animals. The extent of neural cell loss was similar in all monitored areas and in all age groups. At the age of 18 and 35 days, the degenerating cells were observed in the CA1 and CA3 area of the hippocampus and in the ventral and dorsal blade of the dentate gyrus. Numerous glial cells replaced the neuronal population of this region. Some degenerating cells with fragmented nuclei were observed at the age of 90 days. Our experiments confirmed the vulnerability of the developing central nervous system by ethanol intake during the perinatal period and revealed a long-lasting degeneration process in the hippocampus and dentate gyrus.
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