Prevention of infection transmission during stem cell transplantation
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17455799
DOI
10.1007/bf02931627
Knihovny.cz E-resources
- MeSH
- Tissue Donors MeSH
- Child MeSH
- Infections transmission MeSH
- Communicable Disease Control methods MeSH
- Humans MeSH
- Disease Transmission, Infectious prevention & control MeSH
- Seroepidemiologic Studies MeSH
- Hematopoietic Stem Cell Transplantation * MeSH
- Transplantation MeSH
- Virus Diseases prevention & control transmission MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Group of 152 patients (investigated before autologous transplantation) and 35 healthy donors for allogeneic transplantation was examined for the risk of infection transmission that can be associated with the infusion of cryopreserved peripheral blood progenitor cells to the patient and/or cross-contamination of stored grafts. No laboratory signs of active infection were found in 22 donors (63 %) and in 91 patients (60%). The most common was active infection by herpes viruses--50 cases in patients, 21 cases in donors; hepatitis B was found in only two cases. The rate of clinically unsuspected (but dangerous) infections in donors and patients thus remains relatively high in spite of the fact that the system of donor search and the whole transplantation procedure have improved in the last years. The system of safety assurance is extremely important and the whole palette of preventive tests according to EBMT (European Blood and Marrow Transplantation Group) and ISHAGE (International Society for Hemotherapy and Graft Engineering) is fully justified.
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