Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols--precursors and degradation products of chemical warfare agents
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19802902
DOI
10.1002/jms.1674
Knihovny.cz E-resources
- MeSH
- Chemical Warfare Agents chemistry MeSH
- Disulfides chemistry MeSH
- Mass Spectrometry methods MeSH
- Oxidation-Reduction MeSH
- Sulfhydryl Compounds chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chemical Warfare Agents MeSH
- Disulfides MeSH
- Sulfhydryl Compounds MeSH
N,N-dialkylaminoethane-2-thiols belong to the group of precursors and degradation products of chemical warfare agents (CWAs). These compounds were analyzed by means of electrospray ionization-multiple stage mass spectrometry (ion trap) and proposed fragments were confirmed by accurate mass measurement using a QqTOF system. The fragmentation pathways of studied compounds and the products of oxidation (formation of -S-S- linkage) were described. Some minor interesting processes, such as rearrangement of SH group, were observed and proved. A new microLC/MS method, based on ion-pairing chromatography, was developed. Trifluoroacetic acid was employed as an ion-pairing agent to increase the low retention of compounds of interest in the reverse-phase system. The technique was compared with the UPLC/MS method, allowing fast analysis of all the studied thiols as well as an explorative control of originated disulfides.
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