Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect
Language English Country Great Britain, England Media print-electronic
Document type Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
19995475
DOI
10.1017/s0033291709991619
PII: S0033291709991619
Knihovny.cz E-resources
- MeSH
- Affect drug effects MeSH
- Anesthetics, Dissociative blood pharmacology MeSH
- Biomarkers MeSH
- Depressive Disorder drug therapy MeSH
- Adult MeSH
- Double-Blind Method MeSH
- Electroencephalography drug effects MeSH
- Ketamine analogs & derivatives blood pharmacology MeSH
- Cross-Over Studies MeSH
- Humans MeSH
- Predictive Value of Tests MeSH
- Prefrontal Cortex drug effects MeSH
- Theta Rhythm drug effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Anesthetics, Dissociative MeSH
- Biomarkers MeSH
- Ketamine MeSH
- norketamine MeSH Browser
BACKGROUND: Theta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown. METHOD: In a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers. RESULTS: Ketamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion. CONCLUSIONS: Our data indicate that ketamine infusion immediately induces changes similar to those that monoamineric-based antidepressants induce gradually. The reduction in theta cordance could be a marker and a predictor of the fast-acting antidepressant effect of ketamine, a hypothesis that could be tested in depressive patients treated with ketamine.
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