Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20353271
DOI
10.4149/neo_2010_03_215
Knihovny.cz E-zdroje
- MeSH
- antigeny CD38 analýza MeSH
- chromozomální aberace * MeSH
- chronická lymfatická leukemie genetika imunologie metabolismus MeSH
- dospělí MeSH
- imunofenotypizace MeSH
- lidé středního věku MeSH
- lidé MeSH
- mutace MeSH
- protein-tyrosinkináza ZAP-70 analýza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- telomery * MeSH
- těžké řetězce imunoglobulinů genetika MeSH
- variabilní oblast imunoglobulinu genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antigeny CD38 MeSH
- protein-tyrosinkináza ZAP-70 MeSH
- těžké řetězce imunoglobulinů MeSH
- variabilní oblast imunoglobulinu MeSH
- ZAP70 protein, human MeSH Prohlížeč
UNLABELLED: Telomere length was evaluated by terminal repeat fragment method in 66 previously untreated patients with B-chronic lymphocytic leukemia (B-CLL) to ascertain whether telomere shortening was associated with genomic aberrations, immunoglobulin variable heavy chain (IgVH) mutational status, CD38 and ZAP-70 expression, and telomerase activity. Chromosomal aberrations were present in peripheral blood cells of 73% patients (48/66), no difference in telomere length between patients with good and intermediate prognosis according to cytogenetics was found. Association between telomere length and IgVH mutational status, ZAP-70 and CD38 expression was proved as significantly shorter telomeres in patients with unmutated IgVH status (p=0.01) and ZAP-70 positivity (p=0.01) and CD38 positivity (p=0.05) were detected. Telomerase activity was positive in 11 patients out of 21 examined, correlation between telomere length and telomerase activity was found (p=0.05). Telomere length and telomerase activity in combination with other prognostic parameters complete the risk profile of B-CLL patients and might serve for an easy decision on optimal treatment strategy. KEYWORDS: B-chronic lymphocytic leukemia, telomere length, telomerase activity, chromosomal aberrations, prognosis.
Citace poskytuje Crossref.org
