OECD principles of validation of Quantitative Structure - Activity Relationships (QSAR) models for legislative purposes are given and explained. Reasons of their origination and development, like system REACH, are described. A basic impulse has come from some OECD countries followed by all (almost) other countries of the world.

National Institute of Public Health Šrobárova 48 10042 Praha 10 Czech Republic

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Extrapolation of toxic indices among test objects