Antibody persistence and immune memory 4 years post-vaccination with combined hepatitis A and B vaccine in adults aged over 40 years
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- MeSH
- Adult MeSH
- Hepatitis A Antibodies blood MeSH
- Hepatitis A prevention & control MeSH
- Hepatitis B Antibodies blood MeSH
- Hepatitis B prevention & control MeSH
- Immunologic Memory * MeSH
- Vaccines, Combined immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Immunization, Secondary MeSH
- Hepatitis A Vaccines administration & dosage immunology MeSH
- Hepatitis B Vaccines administration & dosage immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Hepatitis A Antibodies MeSH
- Hepatitis B Antibodies MeSH
- Vaccines, Combined MeSH
- Hepatitis A Vaccines MeSH
- Hepatitis B Vaccines MeSH
Persistence of immune response was assessed in adults aged >40 years (N = 596) following primary vaccination with combined hepatitis A/B vaccine or concomitant monovalent hepatitis A and B vaccines. Anti-hepatitis A virus antibody responses persisted for at least 4 years regardless of the vaccine used, with anti-hepatitis B surface antibody responses higher and more sustained in subjects who received the combined hepatitis A/B vaccine. Response rates to an additional dose of the same vaccine(s) used for priming were high.
References provided by Crossref.org
ClinicalTrials.gov
NCT00603252, NCT00684671
