A novel DTPA cross-linking of hyaluronic acid and metal complexation thereof
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21621751
DOI
10.1016/j.carres.2011.04.015
PII: S0008-6215(11)00195-9
Knihovny.cz E-zdroje
- MeSH
- kyselina hyaluronová chemie MeSH
- kyselina pentetová chemie MeSH
- magnetická rezonanční spektroskopie MeSH
- molekulární struktura MeSH
- spektroskopie infračervená s Fourierovou transformací MeSH
- teplota MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kyselina hyaluronová MeSH
- kyselina pentetová MeSH
Macromolecular conjugates of a natural polysaccharide, hyaluronic acid, with diethylenetriaminepentaacetic acid (DTPA)-metal complexes were synthesized and characterized by FTIR, NMR, SEC-MALLS and ICP analysis. Several parameters of the cross-linking reaction as molecular weight of starting HA, temperature, equivalent of DTPA bis-anhydride, concentration of HA, presence of transacylation catalyst DMAP and reaction time were studied. The mechanism for the reaction was suggested and relationship between the molecular weight assigned by SEC-MALLS, reaction parameters and rheological properties of the final cross-linked products were investigated.
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