A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption
Jazyk angličtina Země Německo Médium electronic
Typ dokumentu klinické zkoušky, srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
22080821
DOI
10.1515/cclm.2011.781
PII: /j/cclm.2012.50.issue-2/cclm.2011.781/cclm.2011.781.xml
Knihovny.cz E-zdroje
- MeSH
- aplikace orální MeSH
- biologické markery krev MeSH
- dospělí MeSH
- kolagen typu I krev MeSH
- lidé MeSH
- mladý dospělý MeSH
- omezení příjmu potravy MeSH
- organokovové sloučeniny krev farmakologie MeSH
- parathormon krev MeSH
- peptidy krev MeSH
- referenční standardy MeSH
- regulace genové exprese účinky léků MeSH
- resorpce kosti krev MeSH
- thiofeny krev farmakologie MeSH
- vápník krev farmakologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- biologické markery MeSH
- collagen type I trimeric cross-linked peptide MeSH Prohlížeč
- kolagen typu I MeSH
- organokovové sloučeniny MeSH
- parathormon MeSH
- peptidy MeSH
- strontium ranelate MeSH Prohlížeč
- thiofeny MeSH
- vápník MeSH
BACKGROUND: To investigate the mechanism by which strontium ranelate (SrR) inhibits the bone resorption, this study compared the effects of SrR and calcium on parathyroid hormone (PTH) and the biochemical marker of bone resorption (serum type 1 collagen cross-linked C-telopeptide, βCTX). METHODS: In 10 healthy young subjects, after overnight fasting, 1000 mg of elemental calcium and 2000 mg of SrR containing 600 mg Sr²⁺ were administered consecutively with a 1 week washout period. During the control period no drug was given. Fasting blood samples were drawn at baseline and throughout the next 5-h period. RESULTS: After the ingestion of either calcium or SrR, there was a significant increase in serum calcium and strontium concentrations, and a decrease in serum βCTX and intact PTH concentrations as compared to the baseline values (p<0.05). In the fasting subjects, no significant differences in the variable were found as compared to the baseline values. CONCLUSIONS: The decrease in PTH and the marker of bone resorption observed after the SrR administration is comparable to the decrease observed after the calcium administration in young adults.
Citace poskytuje Crossref.org
Strontium ranelate: in search for the mechanism of action
