Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood
Language English Country United States Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
22362116
DOI
10.1002/dev.21016
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Behavior, Animal drug effects MeSH
- Rats MeSH
- Methamphetamine pharmacology MeSH
- Rats, Wistar MeSH
- Sex Factors MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Methamphetamine MeSH
The aim of the present study was to compare the response to sub-chronic application of methamphetamine (MA) in adulthood in male and female rats prenatally exposed to the same drug. The spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to 5 mg/kg MA or saline (SAL) were tested in a Laboras apparatus (Metris B.V., Netherlands) for five consecutive days, 1 hr daily. MA 1 mg/kg or SAL were used as a challenge prior to testing. Our results showed that rats prenatally exposed to MA were more sensitive to sub-chronic administration of MA in adulthood than prenatally SAL-exposed rats. However, this sensitizing effect of prenatal MA exposure was manifested differently in males and females. In contrast, prenatal MA exposure decreased baseline locomotion in females. This study indicates that gender plays an important role in the sensitivity to MA during prenatal development and in adulthood.
References provided by Crossref.org
An overview of the methamphetamine effect on male sexual behavior and reproductive system
The Impact of Neonatal Methamphetamine on Spatial Learning and Memory in Adult Female Rats
Influence of Prenatal Methamphetamine Abuse on the Brain
Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes
