Receptor for advanced glycation end products (RAGE) and glyoxalase I gene polymorphisms in pathological pregnancy
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22771726
DOI
10.1016/j.clinbiochem.2012.06.031
PII: S0009-9120(12)00335-9
Knihovny.cz E-resources
- MeSH
- Alanine Transaminase blood MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Gene Frequency MeSH
- Genetic Association Studies MeSH
- Cholestasis, Intrahepatic blood genetics MeSH
- Polymorphism, Single Nucleotide * MeSH
- Pregnancy Complications blood genetics MeSH
- Lactoylglutathione Lyase genetics MeSH
- Humans MeSH
- Obstetric Labor, Premature blood genetics MeSH
- Pre-Eclampsia blood genetics MeSH
- Receptor for Advanced Glycation End Products blood genetics MeSH
- Fetal Growth Retardation blood genetics MeSH
- Sequence Analysis, DNA MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alanine Transaminase MeSH
- Biomarkers MeSH
- Lactoylglutathione Lyase MeSH
- Receptor for Advanced Glycation End Products MeSH
OBJECTIVES: The aim of the study was to analyze polymorphisms of receptor for advanced glycation end products (RAGE) gene, and glyoxalase I gene and soluble RAGE, sRAGE, in physiological and pathological pregnancy. DESIGN AND METHODS: Polymorphisms of RAGE gene (-429 T/C, -374 T/A, 557 G/A, 2184 A/G) and glyoxalase I gene (A419C) and sRAGE serum levels were determined in 284 women with pathological and physiological pregnancy. RESULTS: No differences in distribution of genotype and allelic frequencies of studied polymorphisms were found. GA genotype of RAGE 557 G/A polymorphism (known as Gly82Ser) is associated with lower sRAGE serum levels in healthy pregnant women compared to GG genotype (483 ± 104 vs. 692 ± 262 pg/mL, p=0.008). sRAGE correlates negatively with ALT in patients with pregnancy intrahepatic cholestasis (r=-0.536, p=0.05). CONCLUSIONS: We did not show any association of RAGE and glyoxalase I gene polymorphisms with pathological pregnancy, however further studies are needed to confirm the results.
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