Analysis of renal stones by capillary isotachophoresis
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22939127
DOI
10.1016/j.talanta.2012.06.039
PII: S0039-9140(12)00506-1
Knihovny.cz E-resources
- MeSH
- Anions urine MeSH
- Apatites chemistry MeSH
- Phosphates urine MeSH
- Isotachophoresis methods MeSH
- Cations, Divalent urine MeSH
- Cations, Monovalent urine MeSH
- Conductometry MeSH
- Bone and Bones chemistry MeSH
- Uric Acid urine MeSH
- Kidney Calculi chemistry MeSH
- Humans MeSH
- Limit of Detection MeSH
- Oxalates urine MeSH
- Salts urine MeSH
- Carbonates urine MeSH
- Tooth chemistry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anions MeSH
- Apatites MeSH
- Phosphates MeSH
- Cations, Divalent MeSH
- Cations, Monovalent MeSH
- Uric Acid MeSH
- Oxalates MeSH
- Salts MeSH
- Carbonates MeSH
An analytical method for the determination of the composition of renal stones by capillary isotachophoresis with conductometric detection was developed. Using different leading/terminating electrolyte systems, the qualitative and quantitative analysis of organic compounds (urate, xanthate, oxalate) and inorganic ions (phosphate, Ca(2+), Mg(2+), Na(+), NH(4)(+)) species commonly present in mixed renal stones in three separate steps can be carried out with limits of detection about 10 μmol/L. The developed method was validated by the analysis of real samples and can be used for urinary calculi classification. In addition, it was verified that this method can also be employed for the determination of the above mentioned analytes in some other samples (bones, teeth) concerning apatite biominerals (fluoro-, carbonate-, chloro-apatite).
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