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Protein carbonyls and traditional biomarkers in pigs exposed to low-dose γ-radiation

. 2013 Apr ; 94 (2) : 214-8. [epub] 20120925

Language English Country England, Great Britain Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Links

PubMed 23021124
DOI 10.1016/j.rvsc.2012.09.002
PII: S0034-5288(12)00252-4
Knihovny.cz E-resources

Response of pigs to irradiation manifested by production of protein carbonyls and adaptable enzymes was studied in two experiments. In one experiment, 10 mixed-sex pigs were exposed to 0.5 Gy whole body (60)Co irradiation. In the other experiment, another batch of 10 pigs was exposed to 1.0 Gy half-body irradiation. Unlike those exposed to half-body irradiation, the pigs exposed to whole-body irradiation showed significant increase in protein carbonyls by 73%, and a decrease in cholesterol by 25.7%, compared to the control group. In both cases of dose-dependent irradiation exposure, pigs showed a decrease in alanine aminotransferase activity compared with the control group. At the dose of 1 Gy, ALT activity decreased significantly by 27.7%. Aspartate aminotransferase activity in pigs after half-body irradiation decreased significantly by 65.5%. Although low doses of ionizing radiation were applied, monitoring of the above biochemical parameters helped define the pigs' biological response.

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