Late acute myopia syndrome induced by combination of sulfonamide drugs
Language English Country United States Media print
Document type Case Reports, Journal Article
- MeSH
- Acute Disease MeSH
- Anti-Infective Agents adverse effects MeSH
- Anticonvulsants adverse effects MeSH
- Adult MeSH
- Pharyngitis drug therapy MeSH
- Fructose adverse effects analogs & derivatives MeSH
- Trimethoprim, Sulfamethoxazole Drug Combination adverse effects MeSH
- Drug Therapy, Combination MeSH
- Humans MeSH
- Migraine Disorders prevention & control MeSH
- Myopia chemically induced diagnosis MeSH
- Intraocular Pressure drug effects MeSH
- Topiramate MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Anticonvulsants MeSH
- Fructose MeSH
- Trimethoprim, Sulfamethoxazole Drug Combination MeSH
- Topiramate MeSH
We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs. To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a rebound increase in the production of aqueous humor and accumulation of suprachoroidal fluid. It is further postulated that there may be a cumulative effect of sulphonamide drug use on carbonic anhydrase activity in the ciliary body epithelium of susceptible individuals.
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