Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24472505
DOI
10.1016/j.ijbiomac.2014.01.050
PII: S0141-8130(14)00051-8
Knihovny.cz E-resources
- Keywords
- Antibacterial activity, Chitosan derivatives, Fluorescence,
- MeSH
- Anti-Bacterial Agents chemical synthesis chemistry pharmacology MeSH
- Chitosan chemical synthesis chemistry pharmacology MeSH
- Escherichia coli drug effects MeSH
- Fluorescent Dyes chemical synthesis chemistry pharmacology MeSH
- Drug Stability MeSH
- Chemistry Techniques, Synthetic MeSH
- Temperature MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Chitosan MeSH
- Fluorescent Dyes MeSH
The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6-dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: at first, cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro-[1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH-g-AT). The final product of CH-g-AT was separated, purified and re-crystallized by dioxane. The structure of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD, and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid state as well. CH-g-AT showed also high antibacterial activity against gram -ve species (Escherichia coli).
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