Antiurease activity of plants growing in the Czech Republic
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Potentilla species, docking, phenolic constituents, phenol–hypochlorite, urease,
- MeSH
- Algorithms MeSH
- Canavalia enzymology MeSH
- Phenols chemistry isolation & purification pharmacology MeSH
- Flavonoids chemistry isolation & purification pharmacology MeSH
- Galactosides chemistry isolation & purification pharmacology MeSH
- Helicobacter pylori drug effects MeSH
- Helicobacter Infections drug therapy MeSH
- Plants, Medicinal chemistry MeSH
- Potentilla chemistry MeSH
- Quercetin analogs & derivatives MeSH
- Urease antagonists & inhibitors MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Phenols MeSH
- Flavonoids MeSH
- Galactosides MeSH
- myricetin 3-O-glucuronide MeSH Browser
- quercetin-3-O-beta-D-galactopyranoside MeSH Browser
- Quercetin MeSH
- tiliroside MeSH Browser
- Urease MeSH
The antiurease activity of the aqueous extracts of 42 plants growing in the Czech Republic was investigated. A phenol-hypochlorite reaction was used for the determination of ammonia produced by urease. The inhibitory activity of the extracts at a concentration of 0.2 mg/mL varied from 17.8% to 80.0%. Extracts from six Potentilla species expressed inhibitory activity against jack bean urease. They were further investigated for their phenolic constituents and the major compounds were subjected to molecular docking. The results revealed that both jack bean urease and Helicobacter pylori urease were inhibited by quercetin-3-O-β-D-galactopyranoside-6″-gallate (1), myricetin-3-O-β-D-glucuronide (2), tiliroside (3) and B-type procyanidin (4). The antiurease activity of the investigated Potentilla species is probably due to the presence of complex phenolic constituents such as flavonoid glycosides and catechin dimers.
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