Investigation of summation mechanisms in the pupillomotor system
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nitrooční tlak fyziologie MeSH
- pupila účinky záření MeSH
- reflex pupilární fyziologie MeSH
- retina fyziologie MeSH
- světelná stimulace MeSH
- testy zrakového pole * MeSH
- zraková ostrost fyziologie MeSH
- zraková pole fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: To ascertain whether the pupillary response amplitude shows spatial summation of responses with increasing size of retinal stimulation, and to examine the pupillary responses for evidence of surround inhibition, analogous to that found in the receptive fields of the retinal ganglion cells. METHODS: By means of infrared-video-pupillography, the pupil reaction to stimuli of increasing size (1-15°) was measured in 30 normal subjects. Four different retinal locations (0°, 20° and 40° eccentricity on the upper temporal retina and 20° eccentricity on the lower nasal retina) were examined at four different stimulus luminances (17, 47, 87 and 140 cd/m(2)). RESULTS: When the average log amplitude of the pupil light reaction from the 30 subjects is plotted as a function of the log area of the stimulus, a bi-linear response is observed, which is most pronounced for the two higher luminances. The intersection points of the two linear responses are 2.01° in the fovea, 2.80° at 20° upper temporal retina, 2.85° at 20° lower nasal retina and 4.86° at 40° upper temporal retina. CONCLUSIONS: This study suggests that pupillomotor summation areas consist of both summation and inhibitory zones. They show larger diameters than receptive fields of retinal ganglion cells and do not appear to reflect pupillary summation areas of the pretectal olivary nucleus luminance neurons.
Zobrazit více v PubMed
Ophthalmology. 1991 Apr;98(4):485-95; discussion 495-6 PubMed
J Neurophysiol. 2000 Aug;84(2):964-74 PubMed
Science. 2003 Jan 10;299(5604):245-7 PubMed
Klin Monbl Augenheilkd. 2012 Nov;229(11):1083-9 PubMed
J Physiol. 1960 Dec;154:572-80 PubMed
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1970;180(1):12-9 PubMed
Ophthalmologica. 1985;191(1):35-8 PubMed
Eur J Neurol. 2005 Aug;12(8):602-8 PubMed
Exp Brain Res. 1995;106(1):169-76 PubMed
Exp Brain Res. 1996 Nov;112(1):158-62 PubMed
Nat Neurosci. 2001 Jun;4(6):621-6 PubMed
Graefes Arch Clin Exp Ophthalmol. 2009 Jul;247(7):947-53 PubMed
J Neurophysiol. 1953 Jan;16(1):37-68 PubMed
Arch Ophthalmol. 1975 Dec;93(12):1322-7 PubMed
