Mouse Incisor Stem Cell Niche and Myb Transcription Factors
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25182175
DOI
10.1111/ahe.12145
Knihovny.cz E-resources
- MeSH
- Cell Differentiation MeSH
- Stem Cells cytology MeSH
- Mesoderm cytology MeSH
- Mice MeSH
- Stem Cell Niche physiology MeSH
- Cell Proliferation MeSH
- Cell Cycle Proteins metabolism MeSH
- Proto-Oncogene Proteins c-myb metabolism MeSH
- Incisor anatomy & histology embryology MeSH
- Trans-Activators metabolism MeSH
- Gene Expression Regulation, Developmental MeSH
- Dental Enamel cytology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Mybl2 protein, mouse MeSH Browser
- Cell Cycle Proteins MeSH
- Proto-Oncogene Proteins c-myb MeSH
- Trans-Activators MeSH
Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Whereas the reparation of dentin is often observed, enamel does not regenerate in most species. However, in mouse incisor, a population of somatic stem cells in the cervical loop is responsible for the incisor regeneration. Understanding of the specificities of these cells is therefore of an interest in basic research as well as regenerative therapies. The Myb transcription factors are involved in essential cellular processes. B-Myb is often linked to the stem cell phenotype, and c-Myb expression marks undifferentiated and proliferating cells such as the stem cells. In the presented study, temporo-spatial expression of B-Myb and c-Myb proteins was correlated with localisation of putative somatic stem cells in the mouse incisor cervical loop by immunohistochemistry. B-Myb expression was localised mostly in the zone of transit-amplifying cells, and c-Myb was found in the inner enamel epithelium, the surrounding mesenchyme and in differentiated cells. Taken together, neither B-Myb nor c-Myb was exclusively present or abundant in the area of the incisor stem cell niche. Their distribution, however, supports recently reported novel functions of c-Myb in differentiation of hard tissue cells.
Department of Histology and Embryology Masaryk University Kamenice 5 Brno 61265 Czech Republic
Institute of Animal Physiology and Genetics CAS v v i Veveri 97 Brno 602 00 Czech Republic
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