Two SAPP2 gene homologs are present in Candida parapsilosis genome
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Aspartic Acid Proteases chemistry genetics metabolism MeSH
- Candida chemistry enzymology genetics MeSH
- Fungal Proteins chemistry genetics metabolism MeSH
- Genome, Fungal * MeSH
- Molecular Sequence Data MeSH
- Amino Acid Sequence MeSH
- Sequence Alignment MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Aspartic Acid Proteases MeSH
- Fungal Proteins MeSH
Candida parapsilosis produces secreted aspartic proteinases (Saps), which contribute to the virulence of this opportunistic pathogen. Gene family containing as many as 14 sequences potentially encoding secreted aspartic proteinases was identified in C. parapsilosis genome. Of them, SAPP1 and SAPP2 genes have been extensively characterized, but only now do we report that two SAPP2 homologs sharing 91.5 % identity occur in C. parapsilosis genome. Existence of SAPP2 homologs points to unexpected complexity of the SAPP gene family.
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