BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

] CIBER Epidemiologia y Salud Pública 08003 Barcelona Spain

] Unit of Infections and Cancer Cancer Epidemiology Research Programme IDIBELL Catalan Institute of Oncology 08908 Barcelona Spain [2] CIBER Epidemiologia y Salud Pública Madrid Spain

] Unit of Infections and Cancer Cancer Epidemiology Research Programme IDIBELL Catalan Institute of Oncology 08908 Barcelona Spain [2] Department of Medicine University of Barcelona 08036 Barcelona Spain [3] CIBER Epidemiologia y Salud Pública Madrid Spain

Biological Hematology Unit CRB Ferdinand Cabanne Universitary Hospital of Dijon and EA4184 University of Burgundy EA 4184 Dijon France

Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute and MF MU 65653 Brno Czech Republic

Centre de Recherche CHU Sainte Justine Montréal QC Canada H3T 1C4

Centre for Human Exposure Science Institute of Occupational Medicine EH14 4AP Edinburgh UK

Centre of Chronic Immunodeficiency Molecular Epidemiology University Medical Center Freiburg 79106 Freiburg Germany

Department of Epidemiology Biostatistics and Occupational Health Faculty of Medicine McGill University Montréal QC Canada H3A 1A2

Department of Public Health Clinical and Molecular Medicine Occupational Health Section University of Cagliari 09124 Cagliari Italy

Division of Cancer Epidemiology German Cancer Research Center Im Neuenheimer Feld 280 69120 Heidelberg Germany

IARC International Agency for Research on Cancer 69372 Lyon France

Public Health University College Dublin Ireland

Tisch Cancer Institute and Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York 10029 NY USA

Unit of Infections and Cancer Cancer Epidemiology Research Programme IDIBELL Catalan Institute of Oncology 08908 Barcelona Spain

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