The isolation and characterization of actinobacteria from dominant benthic macroinvertebrates endemic to Lake Baikal
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26347255
DOI
10.1007/s12223-015-0421-z
PII: 10.1007/s12223-015-0421-z
Knihovny.cz E-zdroje
- MeSH
- Actinobacteria chemie klasifikace izolace a purifikace metabolismus MeSH
- Amphipoda mikrobiologie MeSH
- antiinfekční látky chemie metabolismus MeSH
- Bacteria účinky léků MeSH
- bezobratlí mikrobiologie MeSH
- fylogeneze MeSH
- hmyz mikrobiologie MeSH
- houby účinky léků MeSH
- jezera mikrobiologie MeSH
- Porifera mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antiinfekční látky MeSH
The high demand for new antibacterials fosters the isolation of new biologically active compounds producing actinobacteria. Here, we report the isolation and initial characterization of cultured actinobacteria from dominant benthic organisms' communities of Lake Baikal. Twenty-five distinct strains were obtained from 5 species of Baikal endemic macroinvertebrates of amphipods, freshwater sponges, turbellaria worms, and insects (caddisfly larvae). The 16S ribosomal RNA (rRNA)-based phylogenic analysis of obtained strains showed their affiliation to Streptomyces, Nocardia, Pseudonocardia, Micromonospora, Aeromicrobium, and Agromyces genera, revealing the diversity of actinobacteria associated with the benthic organisms of Lake Baikal. The biological activity assays showed that 24 out of 25 strains are producing compounds active against at least one of the test cultures used, including Gram-negative bacteria and Candida albicans. Complete dereplication of secondary metabolite profiles of two isolated strains led to identification of only few known compounds, while the majority of detected metabolites are not listed in existing antibiotic databases.
Helmholtz Institute for Pharmaceutical Research Saarland Saarbrucken Germany
Institute of Biology at Irkutsk State University Irkutsk Russia
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Extremophiles. 2012 Jul;16(4):669-79 PubMed
Mol Biotechnol. 2008 Jan;38(1):41-55 PubMed
J Antibiot (Tokyo). 1990 May;43(5):477-84 PubMed
Nat Chem Biol. 2010 Apr;6(4):261-3 PubMed
Mol Biol Evol. 2013 Apr;30(4):772-80 PubMed
Microb Biotechnol. 2014 May;7(3):209-20 PubMed
Mikrobiologiia. 2002 May-Jun;71(3):404-8 PubMed
Mikrobiologiia. 2014 Nov-Dec;83(6):682-93 PubMed
Nat Prod Rep. 2014 Mar;31(3):381-99 PubMed
Bioinformatics. 2012 Jun 15;28(12):1647-9 PubMed
Adv Food Nutr Res. 2012;65:363-87 PubMed
J Chem Inf Comput Sci. 2003 Mar-Apr;43(2):449-57 PubMed
Microb Ecol. 2013 Jan;65(1):232-44 PubMed
J Org Chem. 2001 Jun 15;66(12):4206-13 PubMed
PLoS One. 2008;3(12):e3878 PubMed
Nat Rev Microbiol. 2012 Sep;10(9):641-54 PubMed
Appl Environ Microbiol. 2007 Aug;73(16):5261-7 PubMed
Mol Microbiol. 2010 Apr;76(2):456-66 PubMed
Int J Syst Evol Microbiol. 2007 Nov;57(Pt 11):2578-82 PubMed
Adv Biomed Res. 2014 Jul 31;3:151 PubMed
Appl Microbiol. 1969 Sep;18(3):340-9 PubMed
Microbes Environ. 2014;29(2):211-9 PubMed
Mar Biotechnol (NY). 2013 Aug;15(4):413-24 PubMed
Appl Environ Microbiol. 2011 Jun;77(12):4249-52 PubMed
FEMS Microbiol Ecol. 2014 Nov;90(2):417-23 PubMed
Phytochemistry. 2009 Oct-Nov;70(15-16):1858-66 PubMed
PLoS One. 2013;8(4):e59977 PubMed
Microbiol Res. 2014 Jul-Aug;169(7-8):483-95 PubMed
Agric Biol Chem. 1990 Mar;54(3):791-4 PubMed
Int J Syst Evol Microbiol. 2008 Aug;58(Pt 8):1860-3 PubMed
Environ Entomol. 2013 Aug;42(4):703-10 PubMed
J Am Chem Soc. 2001 Jan 31;123(4):554-60 PubMed
