A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- DNA, antitumor agents, histone deacetylase inhibitors, photoactivation, platinum prodrugs,
- MeSH
- DNA chemistry MeSH
- Photochemistry * MeSH
- Genome MeSH
- Histone Deacetylases metabolism MeSH
- Platinum chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA MeSH
- Histone Deacetylases MeSH
- Platinum MeSH
We report toxic effects of a photoactivatable platinum(IV) complex conjugated with suberoyl-bis-hydroxamic acid in tumor cells. The conjugate exerts, after photoactivation, two functions: activity as both a platinum(II) anticancer drug and histone deacetylase (HDAC) inhibitor in cancer cells. This approach relies on the use of a Pt(IV) pro-drug, acting by two independent mechanisms of biological action in a cooperative manner, which can be selectively photoactivated to a cytotoxic species in and around a tumor, thereby increasing selectivity towards cancer cells. These results suggest that this strategy is a valuable route to design new platinum agents with higher efficacy for photodynamic anticancer chemotherapy.
Institute of Biophysics Academy of Sciences of the Czech Republic v v i Kralovopolska 135 61265 Brno
References provided by Crossref.org
Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs
