Neonatal outcomes in subgroups of women with preterm prelabor rupture of membranes before 34 weeks
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Observational Study, Research Support, Non-U.S. Gov't
- Keywords
- Histological chorioamnionitis, microbial invasion of the amniotic cavity, preterm delivery, short-term neonatal outcome,
- MeSH
- Chorioamnionitis epidemiology microbiology MeSH
- Adult MeSH
- Gestational Age MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Infant, Newborn MeSH
- Neonatal Sepsis epidemiology MeSH
- Amniotic Fluid microbiology MeSH
- Fetal Membranes, Premature Rupture epidemiology MeSH
- Prospective Studies MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
OBJECTIVE: To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on short-term neonatal outcome in women with preterm prelabor rupture of membranes before 34 weeks of gestation. METHODS: A prospective observational cohort study including 122 pregnant women with PPROM between 24+0 and 34+0. MIAC was defined as a positive PCR result for Ureaplasma species, Mycoplasma hominis and Chlamydia trachomatis and/or positive PCR result for the 16S rRNA gene in the amniotic fluid. HCA was defined according to the Salafia classification. Maternal and short-term neonatal outcomes were evaluated according to the presence or absence of MIAC and/or HCA. RESULTS: The presence of both MIAC and HCA was observed in 36% (45/122) of women, HCA alone in 34% (41/122) and MIAC in 5% (6/122). A significantly higher incidence of early onset sepsis was observed in newborns born from women with both MIAC and HCA [33% (15/45)] compared with women with HCA alone [12% (5/41)] or MIAC alone [0% (0/6)] or women without MIAC or HCA detected [0% (0/30); p = 0.001]. CONCLUSIONS: The presence of both MIAC and HCA increases the risk of early onset sepsis in pregnancies complicated by preterm prelabor rupture of membranes before 34 weeks of gestation.
c BCNatal Barcelona Center for Maternal Fetal and Neonatal Medicine Barcelona Spain
g Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
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