Influences of morphine on the spontaneous and evoked excitatory postsynaptic currents in lateral amygdala of rats
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26596324
DOI
10.33549/physiolres.933027
PII: 933027
Knihovny.cz E-resources
- MeSH
- Amygdala drug effects physiology MeSH
- Excitatory Postsynaptic Potentials drug effects physiology MeSH
- Rats MeSH
- Morphine pharmacology MeSH
- Analgesics, Opioid pharmacology MeSH
- Organ Culture Techniques MeSH
- Rats, Sprague-Dawley MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Morphine MeSH
- Analgesics, Opioid MeSH
Acute morphine exposure induces antinociceptive activity, but the underlying mechanisms in the central nervous system are unclear. Using whole-cell patch clamp recordings, we explore the role of morphine in the modulation of excitatory synaptic transmission in lateral amygdala neurons of rats. The results demonstrate that perfusion of 10 microM of morphine to the lateral amygdala inhibits the discharge frequency significantly. We further find that there are no significant influences of morphine on the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). Interestingly, morphine shows no marked influence on the evoked excitatory postsynaptic currents (eEPSCs) in the lateral amygdala neurons. These results indicate that acute morphine treatment plays an important role in the modulation on the excitatory synaptic transmission in lateral amygdala neurons of rats.
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