vox homeobox gene: a novel regulator of midbrain-hindbrain boundary development in medaka fish?
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26965282
DOI
10.1007/s00427-016-0533-8
PII: 10.1007/s00427-016-0533-8
Knihovny.cz E-resources
- Keywords
- Gene regulatory network, Heat shock element, Midbrain-hindbrain boundary, fgf8, medaka, vox,
- MeSH
- Embryo, Nonmammalian metabolism MeSH
- Gene Regulatory Networks MeSH
- Homeodomain Proteins genetics metabolism MeSH
- Mesencephalon embryology metabolism MeSH
- Oryzias embryology genetics MeSH
- Rhombencephalon embryology metabolism MeSH
- Fish Proteins genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Homeodomain Proteins MeSH
- Fish Proteins MeSH
The midbrain-hindbrain boundary (MHB) is one of the key organizing centers of the vertebrate central nervous system (CNS). Its patterning is governed by a well-described gene regulatory network (GRN) involving several transcription factors, namely, pax, gbx, en, and otx, together with signaling molecules of the Wnt and Fgf families. Here, we describe the onset of these markers in Oryzias latipes (medaka) early brain development in comparison to previously known zebrafish expression patterns. Moreover, we show for the first time that vox, a member of the vent gene family, is expressed in the developing neural tube similarly to CNS markers. Overexpression of vox leads to profound changes in the gene expression patterns of individual components of MHB-specific GRN, most notably of fgf8, a crucial organizer molecule of MHB. Our data suggest that genes from the vent family, in addition to their crucial role in body axis formation, may play a role in regionalization of vertebrate CNS.
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