Sex and race differences in QRS duration
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
Grant support
PG/12/77/29857
British Heart Foundation - United Kingdom
PG/13/54/30358
British Heart Foundation - United Kingdom
PubMed
27142220
DOI
10.1093/europace/euw065
PII: euw065
Knihovny.cz E-resources
- Keywords
- Normal healthy subjects, QRS duration, QRS/RR relationship,
- MeSH
- White People statistics & numerical data MeSH
- Black People statistics & numerical data MeSH
- Adult MeSH
- Electrocardiography, Ambulatory MeSH
- Humans MeSH
- Young Adult MeSH
- Heart Conduction System physiology MeSH
- Sex Factors * MeSH
- Heart Rate physiology MeSH
- Healthy Volunteers MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
AIMS: The study investigated healthy subjects to study sex and race differences in QRS durations and the dependency of QRS durations on heart rates and other physiologic correlates. METHODS AND RESULTS: QRS duration and its heart rate dependency were evaluated in 420 615 electrocardiograms obtained in 523 healthy subjects including 111 females of African origin, 130 Caucasian females, 125 males of African origin, and 129 Caucasian males. The distributions of QRS/RR slopes and QRS durations at RR intervals of 1 and 0.5 s were compared between sex- and race-defined subgroups. At high heart rates, QRS duration was increased in ∼35% of all subjects, while in the others, QRS was shortened (no differences between the subgroups). At RR interval of 1 s, the QRS duration was 97.4 ± 4.6, 99.8 ± 6.0, 101.6 ± 5.3, and 104.8 ± 6.3 ms in African females, Caucasian females, African males, and Caucasian males, respectively (all differences P < 0.001). Similar statistical differences were found at an RR of 0.5 s. When accounting for the differences in lean body mass, the difference between African and Caucasian subjects was as large as the difference between females and males. Within each subgroup, the normal QRS durations differed by 15-20 and 18-25 ms at RR intervals of 1 and 0.5 s, respectively. CONCLUSION: The QRS widths are heart rate dependent and different not only between women and men but also between African and Caucasian individuals. Difference in cardiac resynchronization therapy efficacy might be expected between patients of African and Caucasian origin stratified by QRS duration.
1 Medizinische Klinik Technische Universität München Munich Germany
National Heart and Lung Institute Imperial College Dovehouse Street London SW3 6LY UK
University Hospital Brno Masaryk University Brno Czech Republic
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