Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
27272781
PII: 36/6/2719
Knihovny.cz E-zdroje
- Klíčová slova
- Breast cancer, Lactobacillus plantarum, N-nitroso-N-methylurea, melatonin, oligofructose-enriched inulin, prebiotic, probiotic,
- MeSH
- experimentální nádory mléčných žláz farmakoterapie MeSH
- imunologické faktory farmakologie MeSH
- interleukin-6 fyziologie MeSH
- inulin farmakologie MeSH
- krysa rodu Rattus MeSH
- Lactobacillus plantarum * MeSH
- melatonin farmakologie MeSH
- methylnitrosomočovina MeSH
- potkani Sprague-Dawley MeSH
- probiotika farmakologie MeSH
- protinádorové látky farmakologie MeSH
- transformující růstový faktor beta1 fyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- imunologické faktory MeSH
- interleukin-6 MeSH
- inulin MeSH
- melatonin MeSH
- methylnitrosomočovina MeSH
- protinádorové látky MeSH
- transformující růstový faktor beta1 MeSH
BACKGROUND/AIM: Chemopreventive activity of a new probiotic strain Lactobacillus plantarum LS/07 (PRO) and prebiotic oligofructose-enriched inulin (PRE) in rat mammary carcinogenesis induced by procarcinogen 7,12-dimethylbenz[a]anthracene has been reported before. This study evaluated the anticancer and immunomodulatory efficacy of PRO, PRE, PRO+PRE (PRO/PRE) and combination with melatonin (PRO+PRE+MEL) in a rat model, when breast cancer was induced by a direct-acting carcinogen N-nitroso-N-methylurea (NMU). MATERIALS AND METHODS: Daily administration of PRO (at a dose of 8.4×10(8) colony-forming units (c.f.u.)/rat), PRE (in the diet, 20 g/kg) and MEL (in tap water, 20 mg/l) started 14 days before the first NMU dose and lasted for 16 weeks. RESULTS: Although tumor growth was not altered, a marked decrease in the ratio of high-/low-grade carcinomas and in tumoral Ki-67 expression was found after PRO+PRE treatment; melatonin augmented these effects. PRO+PRE+MEL combination enhanced CD4(+) and CD8(+) T-cell tumor infiltration induced by PRO/PRE and increased CD25(+)FoxP3(+) regulatory T-cells in tumors. CONCLUSION: In mammary carcinogenesis, Lactobacillus plantarum LS/07 and inulin exert prodifferentiating, antiproliferative and immunomodulatory activities, which are significantly amplified by melatonin co-administration.
