Quantification of Gait Abnormalities in Healthy-Looking Multiple Sclerosis Patients (with Expanded Disability Status Scale 0-1.5)
Language English Country Switzerland Media print-electronic
Document type Journal Article, Observational Study
PubMed
27497974
DOI
10.1159/000448091
PII: 000448091
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Humans MeSH
- Gait Disorders, Neurologic classification diagnosis MeSH
- Neurologic Examination MeSH
- Disability Evaluation * MeSH
- Multiple Sclerosis classification diagnosis MeSH
- Walking Speed MeSH
- Case-Control Studies MeSH
- Health Status * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
BACKGROUND: Gait impairment is a common symptom in multiple sclerosis (MS) patients, but there is a lack of evidence about gait performance in the group of MS patients with no apparent disability. The aim of our study was to evaluate gait characteristics in MS patients with no apparent impairment of walking and with an Expanded Disability Status Scale (EDSS 0-1.5), and to determine whether any abnormalities are detectable by common clinical tests. METHODS: This was an observational study of 64 MS patients with an EDSS 0-1.5 and 47 age- and sex-matched healthy controls. We measured their performance in the timed 25-foot walk test (T25FWT) and the 2-minute walk test (2MWT). The spatiotemporal parameters of gait were measured using a GAITRite instrument. RESULTS: MS patients with no apparent disability (EDSS 0-1.5) performed worse in T25FWT and 2MWT than normal controls. During the self-selected walking speed test on GAITRite, MS patients had a prolonged double support phase, and during the fast walking speed test, they had lower cadence and decreased step length.
References provided by Crossref.org
Why patients with multiple sclerosis perceive improvement of gait during treatment with natalizumab?
