Differing Lymphatic Vessels Density in Salivary Adenoid Cystic Carcinoma and Pleomorphic Adenoma
Language English Country Switzerland Media print-electronic
Document type Journal Article
PubMed
27837476
DOI
10.1007/s12253-016-0147-5
PII: 10.1007/s12253-016-0147-5
Knihovny.cz E-resources
- Keywords
- Adenoid cystic carcinoma, Lymphangiogenesis, Lymphatic vessel, Pleomorphic adenoma, Salivary gland,
- MeSH
- Carcinoma, Adenoid Cystic metabolism pathology MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphangiogenesis physiology MeSH
- Lymphatic Vessels metabolism pathology MeSH
- Lymphatic Metastasis pathology MeSH
- Young Adult MeSH
- Biomarkers, Tumor metabolism MeSH
- Adenoma, Pleomorphic metabolism pathology MeSH
- Prognosis MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Salivary Glands metabolism pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
Benign and malignant tumours are known to express various factors inducing lymphangiogenesis. Despite their different biological behaviour, salivary pleomorphic adenomas (PA) and adenoid cystic carcinomas (SACC) show similar lymphatic network. Authors compare density of lymphatic network in these tumours. The retrospective study included 20 SACC and 20 PA from salivary tumours. Lymphatic vessel density (LVD) was identified using D2-40 antibody and counted. In SACC, intratumoral, respectively peritumoral, lymphatic vessels were identified in 100 %, respectively 93.8 %, of cases. The intratumoral and peritumoral LVD did not significantly differ from each other. However, they both were higher than normal parenchyma density. In PA, intratumoral LVD, with a single exception, revealed values of 0 and 1. The intratumoral was found to be lower than peritumoral density. The LVD in healthy gland, similar to peritumoral one, was significantly higher than intratumoral values. Direct comparison showed intratumoral and peritumoral LVD in PA to be lower than in SACC. This study comparing LVD in PA and SACC revealed higher values in SACC, outnumbering those in healthy salivary parenchyma and PA. It suggests the capability of this biologically aggressive neoplasm to induce lymphangiogenesis.
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