Chiral separation of benzothiazole derivatives of amino acids using capillary zone electrophoresis
Language English Country Germany Media print-electronic
Document type Journal Article
- Keywords
- amino acids, benzothiazole derivatives, capillary zone electrophoresis, dual cyclodextrin systems, polydimethylacrylamide-coated capillaries,
- MeSH
- Amino Acids chemistry metabolism MeSH
- Benzothiazoles isolation & purification MeSH
- Chemistry Techniques, Analytical methods MeSH
- Cyclodextrins chemistry MeSH
- Electrophoresis, Capillary * MeSH
- Stereoisomerism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Amino Acids MeSH
- Benzothiazoles MeSH
- Cyclodextrins MeSH
A method for the separation of enantiomers of leucine and phenylalanine benzothiazole derivatives as potential antimicrobial agents was developed using capillary zone electrophoresis with a dual cyclodextrin (CD) system. The best resolution of enantiomers was achieved in 100 mmol/L phosphate background electrolyte (pH 3.5) with the dual CD system consisting of 10 mmol/L of β-CD with 10 mmol/L of 2-hydroxypropyl-β-cyclodextrin for leucine derivative and 10 mmol/L of 2-hydroxypropyl-γ-cyclodextrin for phenylalanine derivative, respectively. Under the optimal conditions, the highest enantioresolution of 1.25 was achieved in a noncoated-fused silica capillary at 17°C and 24 kV applied voltage.
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