Depot risperidone-induced adverse metabolic alterations in female rats
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Adipokine, Sprague−Dawley rats, depot risperidone, leptin, lipid profile,
- MeSH
- Adipokines metabolism MeSH
- Antipsychotic Agents adverse effects MeSH
- Weight Gain drug effects MeSH
- Rats MeSH
- Leptin metabolism MeSH
- Lipids MeSH
- Rats, Sprague-Dawley MeSH
- Risperidone adverse effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adipokines MeSH
- Antipsychotic Agents MeSH
- Leptin MeSH
- Lipids MeSH
- Risperidone MeSH
Atypical antipsychotics are associated with adverse metabolic effects including weight gain, increased adiposity, dyslipidaemia, alterations in glucose metabolism and insulin resistance. Increasing evidence suggests that metabolic dysregulation precedes weight gain development. The aim of this study was to evaluate alterations in adipokines, hormones and basic serum biochemical parameters induced by chronic treatment with depot risperidone at two doses (20 and 40 mg/kg) in female Sprague-Dawley rats. Dose-dependent metabolic alterations induced by risperidone after 6 weeks of treatment were revealed. Concomitant to weight gain and increased liver weight, an adverse lipid profile with an elevated triglyceride level was observed in the high exposure group, administered a 40 mg/kg dose repeatedly, while the low dose exposure group, administered a 20 mg/kg dose, developed weight gain without alterations in the lipid profile and adipokine levels. An initial peak in leptin serum level after the higher dose was observed in the absence of weight gain. This finding may indicate that the metabolic alterations observed in this study are not consequent to body weight gain. Taken together, these data may support the primary effects of atypical antipsychotics on peripheral tissues.
Department of Pharmacology Faculty of Medicine Masaryk University Brno Czech Republic
R and D Department Biovendor Laboratorni Medicina Brno Czech Republic
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