Tetanus in adults: results of the multicenter ID-IRI study
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
PubMed
28353183
DOI
10.1007/s10096-017-2954-3
PII: 10.1007/s10096-017-2954-3
Knihovny.cz E-zdroje
- MeSH
- analýza přežití MeSH
- dospělí MeSH
- hodnocení rizik MeSH
- hospitalizace MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tetanus epidemiologie mortalita patologie MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Tetanus is an acute, severe infection caused by a neurotoxin secreting bacterium. Various prognostic factors affecting mortality in tetanus patients have been described in the literature. In this study, we aimed to analyze the factors affecting mortality in hospitalized tetanus patients in a large case series. This retrospective multicenter study pooled data of tetanus patients from 25 medical centers. The hospitals participating in this study were the collaborating centers of the Infectious Diseases International Research Initiative (ID-IRI). Only adult patients over the age of 15 years with tetanus were included. The diagnosis of tetanus was made by the clinicians at the participant centers. Izmir Bozyaka Education and Research Hospital's Review Board approved the study. Prognostic factors were analyzed by using the multivariate regression analysis method. In this study, 117 adult patients with tetanus were included. Of these, 79 (67.5%) patients survived and 38 (32.5%) patients died. Most of the deaths were observed in patients >60 years of age (60.5%). Generalized type of tetanus, presence of pain at the wound area, presence of generalized spasms, leukocytosis, high alanine aminotransferase (ALT) and C-reactive protein (CRP) values on admission, and the use of equine immunoglobulins in the treatment were found to be statistically associated with mortality (p < 0.05 for all). Here, we describe the prognostic factors for mortality in tetanus. Immunization seems to be the most critical point, considering the advanced age of our patients. A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival.
Department of Infectious Diseases Aalborg University Hospital Aalborg Denmark
Department of Infectious Diseases University Hospital Center Mother Teresa Tirana Albania
Infectious Diseases and Intensive Care Unit University Hospital of Pontchaillou Rennes France
Zobrazit více v PubMed
Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1591-9 PubMed
Am J Trop Med Hyg. 2015 Oct;93(4):752-6 PubMed
Emerg Med J. 2009 Dec;26(12 ):845-8 PubMed
J Infect. 2014 Feb;68(2):131-40 PubMed
J Natl Med Assoc. 1991 Jan;83(1):55-8 PubMed
Am J Trop Med Hyg. 2009 May;80(5):827-31 PubMed
Eur J Intern Med. 2014 Jul;25(6):528-32 PubMed
MMWR Recomm Rep. 2006 Dec 15;55(RR-17):1-37 PubMed
MMWR Morb Mortal Wkly Rep. 2012 Jun 29;61(25):468-70 PubMed
Acta Pathol Microbiol Immunol Scand C. 1986 Apr;94(2):77-82 PubMed
Ann Afr Med. 2009 Jul-Sep;8(3):168-72 PubMed
Trop Doct. 2007 Jul;37(3):170-3 PubMed
Intern Med. 2016;55(22):3399-3402 PubMed
Br Med J (Clin Res Ed). 1985 Sep 7;291(6496):648-50 PubMed
Ann Clin Microbiol Antimicrob. 2011 Dec 16;10:38 PubMed
JAMA. 1976 Jan 5;235(1):62-3 PubMed
Niger Postgrad Med J. 2004 Sep;11(3):198-202 PubMed
Med J Malaysia. 2006 Mar;61(1):7-14 PubMed
Am J Med Sci. 2010 Feb;339(2):200-1 PubMed
Trop Doct. 2008 Apr;38(2):104-5 PubMed
Bull Soc Pathol Exot. 2015 Dec;108(5):342-8 PubMed
Trop Doct. 2009 Jan;39(1):39-40 PubMed
