Biological activities of undescribed North American lichen species
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
PubMed
28369962
DOI
10.1002/jsfa.8340
Knihovny.cz E-resources
- Keywords
- Acarospora socialis, Lobothallia alphoplaca, North America, Xanthoparmelia mexicana, biological activities, lichens,
- MeSH
- Anti-Bacterial Agents analysis pharmacology MeSH
- Antioxidants analysis pharmacology MeSH
- Gram-Negative Bacteria drug effects MeSH
- Gram-Positive Bacteria drug effects MeSH
- Humans MeSH
- Lichens chemistry metabolism MeSH
- MCF-7 Cells MeSH
- Cell Proliferation drug effects MeSH
- Antineoplastic Agents analysis pharmacology MeSH
- Plant Extracts pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- North America MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Antioxidants MeSH
- Antineoplastic Agents MeSH
- Plant Extracts MeSH
BACKGROUND: Lichens provide a large array of compounds with the potential for pharmaceutical development. In the present study, extracts from three previously undescribed North American lichen species were examined for antioxidant, antibacterial and anticancer activities. RESULTS: The results from this study demonstrated the following: (i) Acarospora socialis ethanol extract exhibited significant DPPH antioxidant scavenging activities, which were concentration dependent; (ii) acetone and ethyl acetate extracts of Xanthoparmelia mexicana inhibited Gram-positive bacteria but had no effect on Gram-negative bacteria; X. mexicana acetone extract yielded a minimum inhibitory concentration (MIC) of 20.9 µg mL-1 against Staphylococcus aureus, and 41.9 µg mL-1 against Enterococcus faecalis; (iii) acetone extract of Lobothallia alphoplaca inhibited growth of cultured breast cancer MCF-7 cells with an effective concentration (EC50 ) of 87 µg mL-1 ; the MCF-7 cell cycle appears arrested in the G2 phase, whereas the DNA synthesis cell cycle (S) may be inhibited. CONCLUSION: New lichen species that possess strong biological activities have been identified. These lichens comprise secondary metabolites that possess antioxidant, antibacterial and anticancer properties. © 2017 Society of Chemical Industry.
Biorefining Research Institute Lakehead University Thunder Bay ON Canada
Department of Biology Lakehead University Thunder Bay ON Canada
Northern Ontario School of Medicine Lakehead University Thunder Bay ON Canada
South Dakota School of Mines and Technology Rapid City SD USA
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