Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease
Language English Country Great Britain, England Media print-electronic
Document type Comparative Study, Journal Article
PubMed
28542915
DOI
10.1111/jphp.12748
Knihovny.cz E-resources
- Keywords
- Hibiscus sabdariffa, adenine, anthocyanins, chronic kidney disease, rats,
- MeSH
- Adenine toxicity MeSH
- Anthocyanins administration & dosage isolation & purification pharmacology MeSH
- Administration, Oral MeSH
- Renal Insufficiency, Chronic drug therapy physiopathology MeSH
- Hibiscus chemistry MeSH
- Rats MeSH
- Lisinopril pharmacology MeSH
- Disease Models, Animal MeSH
- Rats, Wistar MeSH
- Plant Extracts administration & dosage pharmacology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Adenine MeSH
- Anthocyanins MeSH
- Lisinopril MeSH
- Plant Extracts MeSH
OBJECTIVES: The aim of this work was to assess the possible beneficial effects of aqueous extracts of Hibiscus sabdariffa L. calyces and anthocyanins isolated therefrom in an adenine-induced chronic kidney disease (CKD) model. METHODS: Rats were orally given, for 28 consecutive days, either adenine alone or together with either aqueous extract of H. sabdariffa calyces (5 and 10%) or anthocyanins (50, 100 and 200 mg/kg of anthocyanin concentrate). For comparative purposes, two groups of rats were given lisinopril (10 mg/kg). KEY FINDINGS: When either H. sabdariffa aqueous extract or the anthocyanins isolated from it was administered along with adenine, the adverse effects of adenine-induced CKD were significantly lessened, mostly in a dose-dependent manner. The positive effects were similar to those obtained by administration of lisinopril. CONCLUSIONS: The results obtained show that both H. sabdariffa and its anthocyanins could be considered as possible promising safe dietary agents that could be used to attenuate the progression of human CKD. This could have added significance as H. sabdariffa tea is widely consumed in many parts of Africa and Asia and is thus readily available.
ADINACO Research Group Faculty of Pharmacy Charles University Hradec Králové Czech Republic
Department of Histology Embryology Faculty of Medicine University of Trakya Edirne Turkey
School of Pharmacy and Biomedical Sciences University of Portsmouth Portsmouth Hampshire UK
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