A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
28625666
DOI
10.1016/j.virusres.2017.06.006
PII: S0168-1702(17)30109-0
Knihovny.cz E-resources
- Keywords
- Antibody, Antigen, E protein, Physicochemical properties amino acid residue, Tick-borne encephalitis virus,
- MeSH
- Amino Acids chemistry MeSH
- Antigens, Viral chemistry immunology metabolism MeSH
- Chemical Phenomena MeSH
- Viral Envelope Proteins chemistry immunology metabolism MeSH
- Antibodies, Viral metabolism MeSH
- Protein Binding MeSH
- Encephalitis Viruses, Tick-Borne chemistry immunology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amino Acids MeSH
- Antigens, Viral MeSH
- glycoprotein E, Flavivirus MeSH Browser
- Viral Envelope Proteins MeSH
- Antibodies, Viral MeSH
This work is dedicated to the study of the variability of the main antigenic envelope protein E among different strains of tick-borne encephalitis virus at the level of physical and chemical properties of the amino acid residues. E protein variants were extracted from then NCBI database. Four amino acid residues properties in the polypeptide sequences were investigated: the average volume of the amino acid residue in the protein tertiary structure, the number of amino acid residue hydrogen bond donors, the charge of amino acid residue lateral radical and the dipole moment of the amino acid residue. These physico-chemical properties are involved in antigen-antibody interactions. As a result, 103 different variants of the antigenic determinants of the tick-borne encephalitis virus E protein were found, significantly different by physical and chemical properties of the amino acid residues in their structure. This means that some strains among the natural variants of tick-borne encephalitis virus can potentially escape the immune response induced by the standard vaccine.
Institute of Chemical Biology and Fundamental Medicine SB RAS Novosibirsk Russia
Irkutsk State Medical University Institute of Biomedical Technology Irkutsk Russia
Science Center of Family Health Problems and Human Reproduction Irkutsk Russia
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