Polymorphisms of the receptor for advanced glycation end products and glyoxalase I and long-term outcome in patients with breast cancer
Language English Country United States Media print
Document type Journal Article
- Keywords
- Breast cancer, outcome, oxidative stress, polymorphism, receptor for advanced glycation end products,
- MeSH
- Adult MeSH
- Polymorphism, Single Nucleotide MeSH
- Kaplan-Meier Estimate MeSH
- Lactoylglutathione Lyase genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Breast Neoplasms genetics mortality pathology MeSH
- Receptor for Advanced Glycation End Products genetics MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- GLO1 protein, human MeSH Browser
- Lactoylglutathione Lyase MeSH
- Receptor for Advanced Glycation End Products MeSH
Receptor for advanced glycation end products and glyoxalase I metabolizing advanced glycation end product precursors may play important role in the pathogenesis and progression of cancer. Potential relation between soluble forms of receptor for advanced glycation end products (sRAGE), receptor for advanced glycation end products, glyoxalase I polymorphisms, and long-term outcome (median follow-up of 10.3 years) was studied in 116 patients with breast cancer. Gly82Ser and 2184 A/G RAGE polymorphisms were related to the mortality due to the breast cancer and -419 A/C glyoxalase I polymorphism was related to the overall mortality of the patients suggesting their role not only in the risk of breast cancer but also in the outcome of patients with breast cancer.
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