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PubMed

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A GHEP-ISFG collaborative study on the genetic variation of 38 autosomal indels for human identification in different continental populations

Forensic science international. Genetics. 2018 Jan ; 32 () : 18-25. [epub] 20170922

Forensic Sci Int Genet
ISSN 1878-0326 | 1872-4973
Source

Language English Country Netherlands Media print-electronic

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid29024923

PubMed 29024923
DOI 10.1016/j.fsigen.2017.09.012
PII: S1872-4973(17)30200-4
Knihovny.cz E-resources

Keywords
Allele frequency databases, Forensic genetics, Human identification, Insertion deletion (indel), Population data,
MeSH
Databases, Nucleic Acid MeSH
DNA Fingerprinting MeSH
Ethnicity genetics MeSH
Gene Frequency MeSH
Genotype MeSH
Polymorphism, Single Nucleotide * MeSH
Laboratories statistics & numerical data MeSH
Humans MeSH
Microsatellite Repeats MeSH
INDEL Mutation * MeSH
Genetics, Population * MeSH
Racial Groups genetics MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH

A collaborative effort was carried out by the Spanish and Portuguese Speaking Working Group of the International Society for Forensic Genetics (GHEP-ISFG) to promote knowledge exchange between associate laboratories interested in the implementation of indel-based methodologies and build allele frequency databases of 38 indels for forensic applications. These databases include populations from different countries that are relevant for identification and kinship investigations undertaken by the participating laboratories. Before compiling population data, participants were asked to type the 38 indels in blind samples from annual GHEP-ISFG proficiency tests, using an amplification protocol previously described. Only laboratories that reported correct results contributed with population data to this study. A total of 5839 samples were genotyped from 45 different populations from Africa, America, East Asia, Europe and Middle East. Population differentiation analysis showed significant differences between most populations studied from Africa and America, as well as between two Asian populations from China and East Timor. Low FST values were detected among most European populations. Overall diversities and parameters of forensic efficiency were high in populations from all continents.

Andros Day Surgery Clinic Unilab Forensic Genetics Laboratory Palermo Italy

Departamento de Anatomia y Medicina Legal Laboratorio de periciales Médico Legales de la Universidad de Málaga Spain

Departamento de Biología del Servicio de Criminalística de la Guardia Civil Madrid Spain

Department of Biotechnology Forensic DNA Lab University of the Western Cape Cape Town South Africa

Department of Genetics Institute Criminalistics Prague Prague Czech Republic

DNA Diagnostic Laboratory Rio de Janeiro Brazil

Forensic Science Unit Forensic Genetics Section Basque Country Police Erndio Spain

GENES SAS Medellín Colombia

GENES SAS Medellín Colombia; Instituto de Biologia Universidad de Antioquia Medellín Colombia

Genética Molecular de Colombia Ldta Bogotá Colombia

IACA Laboratorios Bahía Blanca Argentina

Identificación Genética IMBICE Instituto Multidisciplinario de Biologia Celular La Plata Argentina