Multibiomarker Responses of Juvenile Stages of Zebrafish (Danio rerio) to Subchronic Exposure to Polycyclic Musk Tonalide
Language English Country United States Media print-electronic
Document type Journal Article
Grant support
IGA VFU 248/2015/FVHE
Evalutation of tonalid exposure on selected fish species with the emphasis on assessment of endocrine disruption
PubMed
29177677
DOI
10.1007/s00244-017-0484-8
PII: 10.1007/s00244-017-0484-8
Knihovny.cz E-resources
- MeSH
- Antioxidants metabolism MeSH
- Environmental Biomarkers drug effects MeSH
- Water Pollutants, Chemical toxicity MeSH
- Behavior, Animal drug effects MeSH
- Zebrafish * growth & development physiology MeSH
- Glutathione Transferase metabolism MeSH
- Catalase metabolism MeSH
- Oxidative Stress drug effects MeSH
- Lipid Peroxidation drug effects MeSH
- Body Weight drug effects MeSH
- Toxicity Tests, Subchronic methods MeSH
- Tetrahydronaphthalenes toxicity MeSH
- Gills drug effects metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- acetyl methyl tetramethyl tetralin MeSH Browser
- Antioxidants MeSH
- Environmental Biomarkers MeSH
- Water Pollutants, Chemical MeSH
- Glutathione Transferase MeSH
- Catalase MeSH
- Tetrahydronaphthalenes MeSH
Synthetic polycyclic musks, widely used as additives in personal care products, are present in both biotic and abiotic matrices of the aquatic environment at concentrations of ng/l to µg/l. Although they are determined at comparatively low concentrations, these levels are biologically relevant and pose a significant growing risk as stressors to aquatic organisms. The purpose of our study was to evaluate the effects of 28-day-long exposure to polycyclic musk tonalide in zebrafish juvenile stages (Danio rerio) using selected biomarkers. Environmentally relevant concentrations of tonalide caused significant changes in selected enzyme activities in the experimental groups exposed to the highest concentrations. The activity of glutathione S-transferase and lipid peroxidation increased significantly (p < 0.05) after exposure to the highest concentration (50,000 ng/l) compared with the control. A similar trend was observed in catalase activity; there was a significant increase (p < 0.05) after exposure to two highest concentrations of tonalide (5000 and 50,000 ng/l). In addition, a statistically significant decrease (p < 0.05) in glutathione reductase activity was found in the lowest test concentration of tonalide (50 ng/l). None of the tested concentrations resulted in histopathological changes in liver, kidney, skin, or gill. Furthermore, no effects on body weight, body length, specific growth rate, and behavior were observed. Our results showed that tonalide exposure induced profound changes in the activities of antioxidant and detoxifying enzymes, such changes representing an adaptive response of the fish organism to tonalide toxicity.
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