Amniotic fluid pentraxins: Potential early markers for identifying intra-amniotic inflammatory complications in preterm pre-labor rupture of membranes
Language English Country Denmark Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29193454
DOI
10.1111/aji.12789
Knihovny.cz E-resources
- Keywords
- innate immunity, intra-amniotic inflammation, microbial invasion of the amniotic fluid, pattern-recognition molecules, preterm delivery,
- MeSH
- Amniocentesis methods MeSH
- Biomarkers metabolism MeSH
- C-Reactive Protein metabolism MeSH
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Amniotic Fluid metabolism MeSH
- Obstetric Labor, Premature metabolism MeSH
- Fetal Membranes, Premature Rupture metabolism MeSH
- Retrospective Studies MeSH
- Serum Amyloid P-Component metabolism MeSH
- Pregnancy MeSH
- Inflammation metabolism MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- C-Reactive Protein MeSH
- PTX3 protein MeSH Browser
- Serum Amyloid P-Component MeSH
In this study, pentraxin 3 (PTX3), C-reactive protein (CRP), and serum amyloid P component (SAP) concentrations in the amniotic fluid of women with preterm pre-labor rupture of membranes (PPROM) were evaluated based on evidence of microbial invasion of the amniotic cavity (MIAC), intra-amniotic inflammation (IAI), and microbial-associated IAI. A total of 149 women with PPROM were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis. Amniotic fluid PTX3, SAP, and CRP concentrations were assessed using enzyme-linked immunosorbent assay. PTX3 and CRP concentrations were higher in women with MIAC, IAI, and microbial-associated IAI than in women without these conditions. SAP concentrations were only higher in the presence of IAI and microbial-associated IAI. Amniotic fluid PTX3 concentrations of 11 ng/mL were found to be the best value for identifying the presence of microbial-associated IAI and IAI in women with PPROM. To conclude, amniotic fluid pentraxins are involved in intra-amniotic inflammatory responses in pregnancies complicated by PPROM.
Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
Department of Obstetrics and Gynecology Sahlgrenska Academy Gothenburg University Gothenburg Sweden
References provided by Crossref.org
Cervical human papillomavirus infection in women with preterm prelabor rupture of membranes
