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Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch-and-wait strategy after complete resection

Ronceray, Leila
Author Ronceray, Leila Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
Abla, Oussama
Author Abla, Oussama Division of Hematology and Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
Barzilai-Birenboim, Shlomit
Author Barzilai-Birenboim, Shlomit Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petah-Tivka, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Bomken, Simon
Author Bomken, Simon Northern Institute for Cancer Research, Newcastle University, Newcastle, UK
Chiang, Alan Ks
Author Chiang, Alan Ks Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
Jazbec, Janez
Author Jazbec, Janez Division of Pediatrics, Hematology and Oncology, University Medical Center Ljubljana, Ljubljana, Slovenia
Kabickova, Edita
Author Kabickova, Edita Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic
Lazic, Jelena
Author Lazic, Jelena Pediatric Hematology and Oncology, University Children's Hospital, School of Medicine University of Belgrade, Belgrade, Serbia
Beishuizen, Auke
Author Beishuizen, Auke Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Mellgren, Karin
Author Mellgren, Karin Pediatric Hematology and Oncology, The Queen Silvia's Hospital for Children and Adolescents, University of Göteborg, Göteborg, Sweden
Tanaka, Fumiko
Author Tanaka, Fumiko Department of Pediatrics, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan
Pillon, Marta
Author Pillon, Marta ORCID Pediatric Hematology and Oncology, University of Padova, Padova, Italy
Devalck, Christine
Author Devalck, Christine Pediatric Hematology and Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium
Gouttenoire, Marina
Author Gouttenoire, Marina Pediatric Hematology and Oncology, University Hospital, Saint Etienne, France
Makarova, Olga
Author Makarova, Olga Pediatric Hematology and Oncology, University of Münster, Münster, Germany
Burkhardt, Birgit
Author Burkhardt, Birgit Pediatric Hematology and Oncology, University of Münster, Münster, Germany
Attarbaschi, Andishe
Author Attarbaschi, Andishe ORCID Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the International Berlin-Frankfurt-Münster (i-BFM) Study Group
Author European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the International Berlin-Frankfurt-Münster (i-BFM) Study Group

Pediatric blood & cancer. 2018 Apr ; 65 (4) : . [epub] 20171229

Pediatr Blood Cancer
ISSN 1545-5017 | 1545-5009
Source

Language English Country United States Media print-electronic

Document type Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid29286565

PubMed 29286565
DOI 10.1002/pbc.26932
Knihovny.cz E-resources

Keywords
complete resection, marginal zone lymphoma, outcome, watch-and-wait,
MeSH
Child MeSH
Humans MeSH
Lymphoma, B-Cell, Marginal Zone mortality physiopathology therapy MeSH
Survival Rate MeSH
Adolescent MeSH
Follow-Up Studies MeSH
Child, Preschool MeSH
Disease-Free Survival MeSH
Retrospective Studies MeSH
Check Tag
Child MeSH
Humans MeSH
Adolescent MeSH
Male MeSH
Child, Preschool MeSH
Female MeSH
Publication type
Journal Article MeSH
Clinical Trial MeSH
Multicenter Study MeSH
Research Support, Non-U.S. Gov't MeSH

Data on management of pediatric marginal zone lymphoma (MZL) are scarce. This retrospective study assessed characteristics and outcome in 66 patients who were <18 years old. Forty-four (67%) had an extranodal MZL (EMZL), 21 (32%) a nodal MZL (NMZL), and one patient a splenic MZL. Thirty-three patients (50%) received a variable combination of adjuvant chemotherapy/immunotherapy/radiotherapy, while the remainder, including 20 of 21 with NMZL, entered an active observation period. Overall survival was excellent (98 ± 2%), although 11 patients relapsed (17%; NMZL, n = 1; EMZL, n = 10), seven after any therapy and four after complete resection only. In conclusion, outcome of NZML, in particular, seems to be excellent after (in)complete resection and observation only.

Department of Pediatrics and Adolescent Medicine Li Ka Shing Faculty of Medicine Queen Mary Hospital The University of Hong Kong Pokfulam Hong Kong

Department of Pediatrics Saiseikai Yokohamashi Nanbu Hospital Yokohama Japan

Division of Hematology and Oncology Department of Pediatrics Hospital for Sick Children Toronto Canada

Division of Pediatrics Hematology and Oncology University Medical Center Ljubljana Ljubljana Slovenia

Northern Institute for Cancer Research Newcastle University Newcastle UK

Pediatric Hematology and Oncology Charles University and University Hospital Motol Prague Czech Republic

Pediatric Hematology and Oncology Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands

Pediatric Hematology and Oncology Hopital Universitaire des Enfants Reine Fabiola Brussels Belgium

Pediatric Hematology and Oncology Schneider Children's Medical Center of Israel Petah Tivka Israel

Pediatric Hematology and Oncology St Anna Children's Hospital Medical University of Vienna Vienna Austria

Pediatric Hematology and Oncology The Queen Silvia's Hospital for Children and Adolescents University of Göteborg Göteborg Sweden

Pediatric Hematology and Oncology University Children's Hospital School of Medicine University of Belgrade Belgrade Serbia